Engineered macrophage membrane-coated dihydroartemisinin nanoparticles with enhanced CCR2 expression improved symptoms in MRL/LPR mice by metabolic reprogramming of proinflammatory macrophages
The study establishes a mechanistically informed strategy for SLE intervention, substantiated by robust in vitro and in vivo data. These findings lay the foundation for translational research and potential clinical advancement in SLE therapy.
Authors
- Jie Hu (ORCID: https://orcid.org/0009-0003-4783-4942)
- Ruonan Wu (ORCID: https://orcid.org/0009-0008-7849-8255)
- Shuqiu Zhang (ORCID: https://orcid.org/0000-0001-9741-7969)
- Rongrong Wang (ORCID: https://orcid.org/0000-0002-3146-5228)
- Li Zhao (ORCID: https://orcid.org/0000-0001-8842-0074)
- Liyun Zhang (ORCID: https://orcid.org/0000-0002-0814-4872)
- Yanlong Zhang (ORCID: https://orcid.org/0000-0002-8898-2189)
- Jiaqi Yang (ORCID: https://orcid.org/0000-0002-4042-4081)
- Zewen Wu (ORCID: https://orcid.org/0009-0008-9651-4319)
Institutions
- Shanxi Medical University (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s12967-025-06574-4
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China
- Shanxi Provincial Key Research and Development Project