Vascular Normalization Augments the Antitumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors
The challenges of tumor therapy primarily lie in developing novel intervention strategies to shift the tumor microenvironment toward an antitumor phenotype. Herein, we discovered that the combination of HDACi and antiangiogenic therapy promoted the functionality and infiltration of CD8+ T cells, ultimately remodeling the tumor microenvironment and boosting immunotherapy efficacy.
Authors
- Jiajia Hu (ORCID: https://orcid.org/0000-0002-0372-291X)
- Yanxing Chen (ORCID: https://orcid.org/0000-0001-6346-9752)
- Min Wang (ORCID: https://orcid.org/0000-0003-2985-0589)
- Chenyi Wu (ORCID: https://orcid.org/0009-0000-9537-124X)
- Yingnan Wang (ORCID: https://orcid.org/0009-0004-1235-4452)
- Ying Jin (ORCID: https://orcid.org/0000-0001-7105-3052)
- Qi Zhao (ORCID: https://orcid.org/0000-0002-8683-6145)
- Runjie Huang (ORCID: https://orcid.org/0009-0008-7155-0620)
- Feng Wang (ORCID: https://orcid.org/0000-0001-7668-9674)
- Jinling Zhang (ORCID: https://orcid.org/0000-0003-3419-6542)
- Liqin Wang (ORCID: https://orcid.org/0000-0002-9881-6432)
- Lin Tian (ORCID: https://orcid.org/0000-0003-3661-4453)
- Rui‐Hua Xu (ORCID: https://orcid.org/0000-0001-9771-8534)
- Xiaojun Ouyang
- Jiaying Chen (ORCID: https://orcid.org/0009-0006-8903-171X)
Institutions
- Sun Yat-sen University (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1033
- Citations
- 13
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 10.48