Weight-Related Outcomes Among Survivors of Adolescent and Young Adult Cancer after Anti-Obesity Medication Initiation
Anti-obesity medications (AOMs) have not been studied in survivors of adolescent and young adult (AYA) cancer. In this retrospective analysis, generalized additive mixed model with penalized spline described body mass index (BMI) over time among survivors of AYA cancer prescribed an AOM. Body weight and BMI at pre-AOM maximum and last follow-up were summarized, with 95% confidence intervals. Over a median follow-up time of 249 days, 63.4% of survivors had ≥5% weight reduction. The proportion of survivors with severe obesity decreased from 60% to 35%. These findings suggest that AOMs are effective for weight reduction in survivors of AYA cancer.
Authors
- David Santos (ORCID: https://orcid.org/0000-0001-7636-7077)
- Michelle A.T. Hildebrandt (ORCID: https://orcid.org/0000-0001-6769-6872)
- Amy M. Berkman (ORCID: https://orcid.org/0000-0003-0650-3664)
- Sonali Thosani (ORCID: https://orcid.org/0000-0002-4149-3572)
- Michael Roth (ORCID: https://orcid.org/0000-0002-6411-8353)
- Zayd Razouki
- Whittney S. Thoman (ORCID: https://orcid.org/0009-0002-2947-0113)
- Katherine Ramsey Gilmore (ORCID: https://orcid.org/0009-0002-0196-2132)
- Clark R. Andersen (ORCID: https://orcid.org/0000-0003-1846-9117)
- Stephanie B. Dixon (ORCID: https://orcid.org/0000-0003-3901-3274)
- J. Andrew Livingston (ORCID: https://orcid.org/0000-0002-1337-3282)
- Amanda Ramirez
Institutions
- St. Jude Children's Research Hospital (US)
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Journal of Adolescent and Young Adult Oncology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1089/jayao.2025.0031
- Primary Topic
- Pharmacology and Obesity Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00