Serum IL-40 is elevated in systemic sclerosis and is linked to disease activity, gastrointestinal involvement, immune regulation and fibrotic processes
IL-40 was upregulated in the skin and serum of SSc patients and was associated with disease activity, gastrointestinal involvement and fibrotic mediators. Our in vitro findings indicate that IL-40 might be involved in the immune response and fibrotic processes in SSc.
Authors
- Lucie Andrés Cerezo (ORCID: https://orcid.org/0000-0003-1664-5834)
- Ksenia Yu. Bobrova
- Hana Štorkánová (ORCID: https://orcid.org/0000-0002-6416-8385)
- Glenda Alquicer (ORCID: https://orcid.org/0000-0003-1773-5540)
- Ladislav Šenolt (ORCID: https://orcid.org/0000-0001-5500-7312)
- Karel Pavelka (ORCID: https://orcid.org/0000-0003-2743-6296)
- Adéla Navrátilová
- Viktor Bečvář
- Michal Tomčík (ORCID: https://orcid.org/0000-0002-8616-7850)
- Sabína Oreská (ORCID: https://orcid.org/0000-0002-9912-725X)
- Ondřej Kodet (ORCID: https://orcid.org/0000-0002-1382-2535)
- Radim Bečvář (ORCID: https://orcid.org/0000-0003-0022-3135)
- Jiří Vencovský (ORCID: https://orcid.org/0000-0002-0851-0713)
- Marian Rybář
- A. Prokopcova (ORCID: https://orcid.org/0000-0002-8947-5955)
- Aneta Jiránková
- Anna Bobrová
- K. Mocová
Institutions
- Charles University (CZ)
- Institute of Rheumatology (CZ)
- General University Hospital in Prague (CZ)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13075-025-03570-3
- Citations
- 2
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Univerzita Karlova v Praze
- Grantová Agentura, Univerzita Karlova
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Ministerstvo Zdravotnictví Ceské Republiky