Disturbed Repolarization-Relaxation Coupling During Acute Myocardial Ischemia Permits Systolic Mechano-Arrhythmogenesis
Prolonged RRC allows for late-systolic mechano-arrhythmogenesis in acute ischemia, involving contributions of elevated [Ca<sup>2+</sup>]<sub>i</sub>, TRPA1 activity, and reactive oxygen species, which represent potential antiarrhythmic targets.
Authors
- Rémi Peyronnet (ORCID: https://orcid.org/0000-0002-5708-6410)
- T. Alexander Quinn (ORCID: https://orcid.org/0000-0002-2437-5785)
- Breanne A. Cameron (ORCID: https://orcid.org/0000-0003-0334-1217)
- Matthew R. Stoyek (ORCID: https://orcid.org/0000-0002-7539-5962)
- Behzad Taeb
- Peter Baumeister
- Peter Karl Kohl (ORCID: https://orcid.org/0000-0003-0416-6270)
- Sara A. Rafferty (ORCID: https://orcid.org/0000-0003-2869-9389)
- Flavio H. Fenton (ORCID: https://orcid.org/0000-0002-4089-8850)
- Joachim Greiner (ORCID: https://orcid.org/0000-0001-5454-2962)
- Tarek Lawen (ORCID: https://orcid.org/0000-0002-2290-062X)
- Ilija Uzelac (ORCID: https://orcid.org/0000-0003-3743-5342)
Institutions
- Dalhousie University (CA)
- Georgia Institute of Technology (US)
- University of Freiburg (DE)
- Virginia Commonwealth University (US)
- University of Education Freiburg (DE)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1161/circresaha.124.326057
- Citations
- 3
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 4.16