Plumbagin ameliorates ferroptosis of ovarian granulosa cells in polycystic ovary syndrome by down-regulating SLC7A5 m6A methylation modification through inhibition of YTHDF1
PLB ameliorates DHT-induced mitochondrial dysfunction and ferroptosis in KGN cells by inhibiting YTHDF1 expression, and its action is dependent on the mechanism by which YTHDF1 regulates SLC7A5 translation through m6A modification. Downregulating YTHDF1 or SLC7A5 significantly enhances GC survival and function.
Authors
- Cai ZhaoWei (ORCID: https://orcid.org/0000-0002-0798-9072)
- Rongju Liu (ORCID: https://orcid.org/0000-0001-5463-5042)
- RuoPeng Zhang
- Li Zhao (ORCID: https://orcid.org/0000-0003-0856-1665)
- Zhou Li-ling
Institutions
- Songshan Lake Materials Laboratory (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13048-025-01700-8
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province