IL-6R blockade combined with immunosuppressants alleviates adult-onset Still’s disease through immune remodeling: a mass cytometry study
Combined IL-6R blockade effectively modulates immune dysregulation in refractory AOSD, reversing key pathological immune alterations and highlighting its therapeutic potential.
Authors
- Liangjing Lu (ORCID: https://orcid.org/0000-0001-9116-6038)
- Yixuan Li (ORCID: https://orcid.org/0000-0003-4040-4336)
- Ting Zhang (ORCID: https://orcid.org/0000-0002-9569-9357)
- Xuesong Liu (ORCID: https://orcid.org/0000-0002-7736-0077)
- Xianting Ding (ORCID: https://orcid.org/0000-0002-1549-3499)
- Xiaoxiang Chen (ORCID: https://orcid.org/0000-0002-2400-4749)
- Ruru Guo (ORCID: https://orcid.org/0000-0003-0066-9153)
- Xinyu Meng (ORCID: https://orcid.org/0000-0001-6158-8491)
- Tong Lei (ORCID: https://orcid.org/0000-0001-9004-0409)
Institutions
- Renji Hospital (CN)
- State Key Laboratory of Oncogene and Related Genes (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s12967-025-06597-x
- Citations
- 3
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 5.31
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities