Neuregulin 1β enhances pulmonary vein arrhythmogenesis by modulating electrophysiological characteristics, calcium and sodium homeostasis via the <scp>AKT</scp>/<scp>CaMKII</scp> pathway
By modulating electrophysiological characteristics, Ca<sup>2+</sup> homeostasis, and enhancing oxidative stress through AKT/CaMKII signalling, NRG1β increased PV arrhythmogenesis with increasing RyR-dependent SR Ca<sup>2+</sup> leak of PV cardiomyocytes.
Authors
- Yen‐Yu Lu (ORCID: https://orcid.org/0000-0002-3010-3209)
- Satoshi Higa (ORCID: https://orcid.org/0000-0002-5735-6249)
- Shih‐Yu Huang (ORCID: https://orcid.org/0000-0002-8038-1813)
- Yao‐Chang Chen (ORCID: https://orcid.org/0000-0001-6589-6993)
- Wei‐Shiang Lin (ORCID: https://orcid.org/0000-0003-0559-6264)
- Yi‐Jen Chen (ORCID: https://orcid.org/0000-0001-7224-4491)
- Shih‐Ann Chen
Institutions
- Fu Jen Catholic University (TW)
- Tri-Service General Hospital (TW)
- National Chung Hsing University (TW)
- China Medical University (TW)
- Taipei Veterans General Hospital (TW)
- Taichung Veterans General Hospital (TW)
- China Medical University Hospital (TW)
- Cathay General Hospital (TW)
- Tomishiro Central Hospital (JP)
- Wan Fang Hospital (TW)
- Taipei Medical University (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1111/eci.70084
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cathay General Hospital
- Tri-Service General Hospital
- National Science and Technology Council