Combining topiramate with prolonged exposure therapy improves PTSD symptoms

Military veterans with comorbid post‐traumatic stress disorder (PTSD) and alcohol use disorder (AUD) who received topiramate in combination with prolonged exposure therapy (PE) showed greater improvement in PTSD symptoms than those receiving PE alone, a new study has found. The combination treatment did not lead to significant improvement in alcohol use outcomes compared with PE alone. Study results were published online March 19, 2025, in the American Journal of Psychiatry .

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2025-06-02
DOI
https://doi.org/10.1002/pu.31320
Primary Topic
Treatment of Major Depression
Type
article
Field-Weighted Citation Impact
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article

Combining topiramate with prolonged exposure therapy improves PTSD symptoms

The Brown University Psychopharmacology Update
Treatment of Major Depression
article

Combining topiramate with prolonged exposure therapy improves PTSD symptoms

article en

Abstract

Military veterans with comorbid post‐traumatic stress disorder (PTSD) and alcohol use disorder (AUD) who received topiramate in combination with prolonged exposure therapy (PE) showed greater improvement in PTSD symptoms than those receiving PE alone, a new study has found. The combination treatment did not lead to significant improvement in alcohol use outcomes compared with PE alone. Study results were published online March 19, 2025, in the American Journal of Psychiatry .

The Brown University Psychopharmacology UpdateVol. 36(7)
Openalex Percentile: Top 86%
Treatment of Major Depression
DOISourceOpenAlex
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Combining topiramate with prolonged exposure therapy improves PTSD symptoms · The Brown University Psychopharmacology Update (2025) | TGRS Research Map | TGRS