Review of GLP‐1 trials finds low incidence of suicide risk

A systematic review and meta‐analysis comprising 27 trials comparing glucagon‐like peptide 1 (GLP‐1) receptor agonists and placebo in patients with type 2 diabetes or obesity found no significantly increased risk of suicidal behavior in conjunction with the popular medications. The incidence of suicide and self‐harm was very low in both the GLP‐1 and placebo groups. Results of the review were published online March 19, 2025, in JAMA Psychiatry .

Publication Details

Journal
The Brown University Psychopharmacology Update
Published
2025-06-02
DOI
https://doi.org/10.1002/pu.31321
Primary Topic
Diet and metabolism studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Review of GLP‐1 trials finds low incidence of suicide risk

The Brown University Psychopharmacology Update
Diet and metabolism studies
article

Review of GLP‐1 trials finds low incidence of suicide risk

article en

Abstract

A systematic review and meta‐analysis comprising 27 trials comparing glucagon‐like peptide 1 (GLP‐1) receptor agonists and placebo in patients with type 2 diabetes or obesity found no significantly increased risk of suicidal behavior in conjunction with the popular medications. The incidence of suicide and self‐harm was very low in both the GLP‐1 and placebo groups. Results of the review were published online March 19, 2025, in JAMA Psychiatry .

The Brown University Psychopharmacology UpdateVol. 36(7)
Openalex Percentile: Top 83%
Diet and metabolism studies
DOIOpen Access PDFOpenAlex
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Review of GLP‐1 trials finds low incidence of suicide risk · The Brown University Psychopharmacology Update (2025) | TGRS Research Map | TGRS