<scp>CD300A</scp><sup>+</sup><scp>CD8</scp><sup>+</sup> T Cells as Predictive Biomarkers for Achieving Functional Cure in Chronic Hepatitis B Patients Undergoing Pegylated Interferon‐Alpha Therapy
CD300A<sup>+</sup> CD8<sup>+</sup> T cells are enriched in patients achieving FC during PEG-IFN-α therapy, exhibiting robust clonal expansion, enhanced cytotoxicity and HBV antigen specificity. These cells may serve as potential biomarkers for treatment response to improve FC rates in CHB therapy.
Authors
- You‐Yuan Wang
- Yan‐Mei Jiao (ORCID: https://orcid.org/0000-0002-2556-326X)
- Junliang Fu (ORCID: https://orcid.org/0009-0001-8318-6888)
- Ruonan Xu (ORCID: https://orcid.org/0000-0002-4180-7754)
- Wen‐Xin Wang
- Ming‐Ju Zhou (ORCID: https://orcid.org/0000-0001-8467-726X)
- Zhen Cheng (ORCID: https://orcid.org/0000-0003-3056-5611)
- Xing Fan (ORCID: https://orcid.org/0000-0002-0809-9207)
- Qiuting Lv (ORCID: https://orcid.org/0009-0004-6055-3499)
- Si‐Yuan Chen
- Jin‐Wen Song (ORCID: https://orcid.org/0000-0002-8582-8012)
- Jing Li
- Peng Zhang (ORCID: https://orcid.org/0000-0002-6218-1885)
- Chao Zhang (ORCID: https://orcid.org/0000-0001-8126-8145)
- Fu‐Sheng Wang (ORCID: https://orcid.org/0000-0002-8043-6685)
- Ming Shi (ORCID: https://orcid.org/0000-0002-9905-6316)
- Meng‐Meng Zhu
Institutions
- University of Science and Technology of China (CN)
- Peking University (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1111/apt.70214
- Citations
- 1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Beijing Nova Program
- National Key Research and Development Program of China