KCNK2-mediated regulation of MMP-2/9 by PlGF influences uterine artery function in pregnancy-induced hypertension
2,2,2 Trichloroethanol activates KCNK2, elevates MMP 2/9, and improves uterine arterial endothelial function, while PlGF synergizes with KCNK2 signaling to potentiate these effects. The PlGF KCNK2 MMP 2/9 axis plays a pivotal regulatory role in the vascular pathology of PIH, highlighting its potential as a therapeutic target for PIH related vascular dysfunction.
Authors
- Ridong Zhou
- Meiyu Chen (ORCID: https://orcid.org/0000-0002-1247-0419)
- Mingfu Chen
- Jichang Zheng
- Xiaobin Chen (ORCID: https://orcid.org/0000-0001-9213-5479)
- Gongxin Yang
- Hu Zhao (ORCID: https://orcid.org/0000-0001-7796-6944)
- Hongming Lin
- Chen Lin
- Jing Tu
- Yinzhen Chen
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fujian Medical University (CN)
- Xiamen University (CN)
- Fuzhou General Hospital of Nanjing Military Command (CN)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s12884-025-07743-5
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province
- Fujian University of Traditional Chinese Medicine