Population pharmacokinetics and pharmacogenomics of edoxaban in Japanese adults with atrial fibrillation
These results suggest that genetic polymorphisms of CYP3A5 and ABCB1 are not considered intrinsic factors affecting edoxaban pharmacokinetics in Japanese adult AF patients. Similarly to previous studies, renal function affects its pharmacokinetics. These findings may provide useful information for individualized anticoagulant therapy with edoxaban to prevent adverse events without reference to genetic polymorphisms of CYP3A5 and ABCB1.
Authors
- Yohei Tabuchi
- Toshiya Katsura (ORCID: https://orcid.org/0000-0002-7789-8803)
- Minoru Horie (ORCID: https://orcid.org/0000-0002-9029-2339)
- Satoshi Ueshima (ORCID: https://orcid.org/0000-0002-8828-1083)
- Masaharu Akao
- Hideki Itoh (ORCID: https://orcid.org/0000-0002-5104-3313)
- Daiki Hira (ORCID: https://orcid.org/0000-0001-8344-2469)
- Tomoya Ozawa (ORCID: https://orcid.org/0000-0002-3105-8278)
- Takanori Aizawa (ORCID: https://orcid.org/0000-0001-5192-3962)
- Moritake Iguchi (ORCID: https://orcid.org/0000-0001-5029-1203)
- Yoshihisa Nakagawa (ORCID: https://orcid.org/0000-0002-9411-9314)
- Asami Kashiwa (ORCID: https://orcid.org/0000-0001-9562-8981)
- Takeru Makiyama (ORCID: https://orcid.org/0000-0002-9471-5335)
- Sayana Matsuda
- Tomohiro Terada (ORCID: https://orcid.org/0000-0002-4559-9753)
- Satoshi Shizuta
- Rio Michihata
Institutions
- Ritsumeikan University (JP)
- Shiga University of Medical Science (JP)
- Kyoto University (JP)
- Kyoto Medical Center (JP)
- Shiga University of Medical Science Hospital (JP)
- Niigata City General Hospital (JP)
- Kyoto University Hospital (JP)
Publication Details
- Journal
- Journal of Pharmaceutical Health Care and Sciences
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s40780-025-00453-2
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science
- Daiichi Sankyo Company
- Daiichi Sankyo Europe