Multi-omics unveils BCAA metabolism markers L-leucine and HMGCS1 as prognostic marker for immunotherapy efficacy in non-small cell lung cancer
This study identifies a BCAA-related plasma metabolites and gene signature as effective prognostic markers for NSCLC patients receiving immunotherapy, with HMGCS1 as a key prognostic factor influencing tumor progression and immune response.
Authors
- Lin Li (ORCID: https://orcid.org/0000-0001-6980-139X)
- Li‐Ling Huang (ORCID: https://orcid.org/0000-0002-7558-603X)
- Le Tang (ORCID: https://orcid.org/0000-0002-5192-3329)
- Jiarui Yao (ORCID: https://orcid.org/0000-0002-9835-395X)
- Yuankai Shi (ORCID: https://orcid.org/0000-0002-8685-6744)
- Xiaohong Han (ORCID: https://orcid.org/0000-0002-4070-207X)
- Liyuan Dai (ORCID: https://orcid.org/0009-0007-4848-3709)
- Ning Lou (ORCID: https://orcid.org/0000-0002-4920-5037)
- Xinzheng Wang (ORCID: https://orcid.org/0000-0001-8757-8697)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s12931-025-03277-8
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital