IRE1α-mediated endoplasmic reticulum stress response regulates oxidative damage in CYP4V2 deficient human retinal pigment epithelial cells
Our findings reveal a novel regulatory mechanism involving potential reduction in PUFA utilization, IRE1α signaling mediated ER oxidative stress, and mitochondrial dysfunction in BCD, potentially offering future therapeutic avenues.
Authors
- Chang‐Chun Hsiao (ORCID: https://orcid.org/0000-0002-7275-4675)
- Jong‐Jer Lee (ORCID: https://orcid.org/0000-0002-9213-0288)
- Yu‐Ting Hsiao (ORCID: https://orcid.org/0000-0001-5739-7967)
Institutions
- Chang Gung University (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Biomedical Journal
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.bj.2025.100875
- Citations
- 2
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.30
Funders
- Chang Gung Memorial Hospital
- Chang Gung Medical Foundation
- National Science and Technology Council