Pexidartinib Inhibits Macrophage Senescence Through Glycolysis in Periodontitis Microenvironment
Our findings indicate that PLX3397 alleviates periodontal tissue inflammation by inhibiting macrophage senescence via glycolytic modulation, offering potential for immune-regulatory therapies in periodontitis management.
Authors
- Ai Tian (ORCID: https://orcid.org/0009-0000-1849-0624)
- Wei Yan (ORCID: https://orcid.org/0000-0002-3060-4353)
- Li Li (ORCID: https://orcid.org/0000-0003-2342-3658)
- Jie Zhang (ORCID: https://orcid.org/0000-0003-0242-8812)
- Yiting Yuan
- Yongchun Zhang (ORCID: https://orcid.org/0009-0009-9949-0604)
- Hui Fang (ORCID: https://orcid.org/0009-0006-8619-3043)
- Jifan Zhan
- Tianjiao Xiao
- Jiabing Kang
Institutions
- Guiyang Medical University (CN)
- Philipps University of Marburg (DE)
- Kunming Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.identj.2025.100843
- Citations
- 4
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 5.86
Funders
- Health Commission of Guizhou Province
- National Natural Science Foundation of China
- Natural Science Foundation of Guizhou Province