The molecular impact of cigarette smoking resembles aging across tissues
Overall, our multi-tissue and multi-omic analysis of the effects of cigarette smoking provides an extensive characterization of the impact of tobacco smoke across tissues and unravels the molecular mechanisms driving smoking-induced tissue homeostasis decline and aging acceleration.
Authors
- Athos Moraes (ORCID: https://orcid.org/0009-0009-5352-8304)
- Rogério Ribeiro (ORCID: https://orcid.org/0000-0002-5468-7608)
- Oleksandra Soldatkina (ORCID: https://orcid.org/0000-0003-4841-1039)
- Raquel García-Pérez (ORCID: https://orcid.org/0000-0002-2573-6984)
- Winona Oliveros (ORCID: https://orcid.org/0000-0002-3646-8874)
- Pedro G. Ferreira (ORCID: https://orcid.org/0000-0003-3838-8664)
- José Miguel Ramírez (ORCID: https://orcid.org/0000-0001-7881-1506)
- Marta Melé
Institutions
- Universidade do Porto (PT)
- Barcelona Supercomputing Center (ES)
- INESC TEC (PT)
- Universitat de Barcelona (ES)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13073-025-01485-x
- Citations
- 11
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- Broad Institute
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- Fundação para a Ciência e a Tecnologia
- Agencia Estatal de Investigación
- European Social Fund