Associations between HLA-II variation and antibody specificity are predicted by antigen properties
Hence, genetic associations to antibody specificities are shaped by antigen intrinsic properties. Given the prominent role of HLA-II alleles in infection, autoimmune diseases, allergies, and cancer, our work provides a theoretical framework to study antigen/HLA-II risk factors in these disease settings and will fuel the design of improved immunogenetics screens.
Authors
- Thomas J. Vogl (ORCID: https://orcid.org/0000-0002-3892-1740)
- Máté Manczinger (ORCID: https://orcid.org/0000-0003-0831-9617)
- Gabriel Innocenti (ORCID: https://orcid.org/0000-0002-9380-4045)
- Sergio Andreu‐Sánchez (ORCID: https://orcid.org/0000-0002-3503-9971)
- Hesham ElAbd (ORCID: https://orcid.org/0000-0003-1844-8279)
- Iros Barozzi (ORCID: https://orcid.org/0000-0003-0690-3473)
- Nicolai V Hörstke (ORCID: https://orcid.org/0009-0003-8245-7740)
- Andre Franke
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- University of Szeged (HU)
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
- Hochschule für Angewandte Wissenschaften Kiel (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Hospital Schleswig-Holstein (DE)
- Clinical Research Center Kiel (DE)
- Medical University of Vienna (AT)
- University of Lübeck (DE)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13073-025-01486-w
- Citations
- 5
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- FP7 Ideas: European Research Council
- HORIZON EUROPE Health