Bisacurone ameliorates myocardial ischemia/reperfusion injury in rats: regulation of inflammatory and apoptosis pathways via CHOP/GRP78 proteins
The findings of this study suggest that bisacurone exerts its cardioprotective effects by inhibiting oxido-nitrosative stress, inflammatory release (TNF-α, IL-1β, and TGF-β), apoptosis (Bax and Caspase-3), and by regulating the expression of CHOP and GRP78.
Authors
- Xiaoming Yang (ORCID: https://orcid.org/0000-0003-3629-0946)
- Dawei Zhu (ORCID: https://orcid.org/0000-0003-0167-6603)
- Xiaoyun Liao (ORCID: https://orcid.org/0000-0002-6709-1520)
- Jing Feng (ORCID: https://orcid.org/0000-0003-1229-4352)
- Qi Wang (ORCID: https://orcid.org/0000-0003-2108-3266)
- Kun Wang (ORCID: https://orcid.org/0000-0002-2793-7923)
- Yuan Yao
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s40360-025-00949-5
- Citations
- 1
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Chengdu Science and Technology Bureau