A new benzoate derivative from <i>Talaromyces fusiformis</i> , an endophytic fungus cultured from <i>Hypecoum leptocarpum</i> Hook. f. et. Thoms
A new benzoate derivative, 2, 3, 4, 5-tetrahydroxypentyl-4- (3-hydroxy-3-methylbutoxy) benzoate (1) and four known ones, including xylityl-4-hydroxybenzoates (2), fuscoatramide (3), talarodride H (4), and talarodride G (5) were isolated from <i>Hypecoum leptocarpum-</i>derived endophytic fungus <i>Talaromyces fusiformis</i> in this study. The compound structures were determined by means of UV, IR, HRESIMS, and NMR. The cytotoxic activities of these compounds were evaluated using the MTT assay. Talarodride G effectively inhibited human breast adenocarcinoma (MCF-7) cell lines with an IC<sub>50</sub> value of 24.97 μg/mL.
Authors
- Huaixiu Wen (ORCID: https://orcid.org/0000-0002-0490-3659)
- Caixia Li (ORCID: https://orcid.org/0000-0002-8170-432X)
- Rong Guo (ORCID: https://orcid.org/0000-0003-0000-2543)
- Ting An (ORCID: https://orcid.org/0009-0007-7193-7828)
- Hui Ling Tan
Institutions
- Qinghai Tibetan Hospital (CN)
- Institute of Tibetan Plateau Research (CN)
- University of Chinese Academy of Sciences (CN)
- Northwest Institute of Plateau Biology
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1080/14786419.2025.2512575
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Qinghai