Neoadjuvant Osimertinib for Resectable <i>EGFR</i> -Mutated Non–Small Cell Lung Cancer
Neoadjuvant osimertinib with or without chemotherapy demonstrated statistically significant improvement in the MPR rate over chemotherapy alone in patients with resectable, <i>EGFR</i>-mutated, stage II-IIIB NSCLC.
Authors
- Yasuhiro Tsutani (ORCID: https://orcid.org/0000-0001-8836-1027)
- Ligang Xing (ORCID: https://orcid.org/0000-0002-0528-9048)
- David J. Finley
- Jair Bar (ORCID: https://orcid.org/0000-0002-1224-3646)
- Julia Rotow (ORCID: https://orcid.org/0000-0003-4547-2960)
- Mustafa Dikilitaş (ORCID: https://orcid.org/0000-0002-3763-7529)
- Bentong Yu (ORCID: https://orcid.org/0000-0001-6396-1931)
- Alex Martínez‐Martí (ORCID: https://orcid.org/0000-0002-6714-9526)
- Collin M. Blakely (ORCID: https://orcid.org/0000-0001-8134-3651)
- Justyna Rawluk
- Maximilian J. Hochmair (ORCID: https://orcid.org/0000-0002-8673-2450)
- Akira Ono (ORCID: https://orcid.org/0000-0001-5705-9423)
- Shuji Murakami (ORCID: https://orcid.org/0000-0001-5104-5493)
- Noriko Yanagitani
- Toshi Menju
- Prabhat Singh Malik (ORCID: https://orcid.org/0000-0003-0205-8559)
- Yuri Rukazenkov
- Chao-Hsun Chen
- Elizabeth Dudnik (ORCID: https://orcid.org/0000-0001-6971-3576)
- Gaofeng Li (ORCID: https://orcid.org/0000-0003-3628-815X)
- Buhai Wang (ORCID: https://orcid.org/0000-0001-6391-4502)
- Hidemi Suzuki (ORCID: https://orcid.org/0000-0002-8983-433X)
- Erminia Massarelli (ORCID: https://orcid.org/0000-0001-7798-7286)
- Yuh‐Min Chen (ORCID: https://orcid.org/0000-0003-0585-8463)
- Dat T. Vo (ORCID: https://orcid.org/0000-0001-9088-7132)
- Froylán López-López
- W. Weder
- Seung Soo Yoo (ORCID: https://orcid.org/0000-0002-7309-9254)
- Piyada Sitthideatphaiboon (ORCID: https://orcid.org/0000-0003-2098-1646)
- Somcharoen Saeteng (ORCID: https://orcid.org/0000-0001-7603-9153)
- Hiroshi Tanaka (ORCID: https://orcid.org/0000-0001-7057-813X)
- Sun Hyo Park (ORCID: https://orcid.org/0000-0002-9464-0652)
- Miyako Satouchi (ORCID: https://orcid.org/0000-0003-0613-9487)
- Óscar Arrieta (ORCID: https://orcid.org/0000-0002-1164-3779)
- Ming‐Hsun Wu (ORCID: https://orcid.org/0000-0002-8811-9203)
- Jonathan Wade Goldman (ORCID: https://orcid.org/0000-0002-4925-8243)
- P. K. Yаblonskiy (ORCID: https://orcid.org/0000-0003-4385-9643)
- José Fernando Bastos de Moura
- Velko Minchev
- Jusang Kim
- Hien P. Nguyen (ORCID: https://orcid.org/0000-0002-7113-8010)
- Alexander I. Spira (ORCID: https://orcid.org/0000-0003-1303-0447)
- Ulrich Richter
- Masahiro Tsuboi (ORCID: https://orcid.org/0000-0003-3031-5807)
- Maria Paz Saavedra
- Jin‐Yuan Shih (ORCID: https://orcid.org/0000-0002-2854-5067)
- Wentao Fang (ORCID: https://orcid.org/0000-0002-6517-9975)
- Jonathan Spicer (ORCID: https://orcid.org/0000-0003-2708-1309)
- Marc de Perrot (ORCID: https://orcid.org/0000-0003-2000-9427)
- Clarissa Baldotto (ORCID: https://orcid.org/0000-0001-9539-3094)
- Mehmet Alı Nahıt Şendur (ORCID: https://orcid.org/0000-0001-7021-6139)
- Adam J. Bograd (ORCID: https://orcid.org/0000-0002-5855-7245)
- Diego Cortinovis (ORCID: https://orcid.org/0000-0001-7611-7369)
- Carles Escriu (ORCID: https://orcid.org/0000-0003-3638-3202)
- Guzel Mukhametshina
- Ian C. Anderson (ORCID: https://orcid.org/0000-0002-3507-163X)
- Ming Zhou (ORCID: https://orcid.org/0009-0006-2055-7756)
- Jiro Okami (ORCID: https://orcid.org/0000-0002-7633-9700)
- Marcelo Garrido (ORCID: https://orcid.org/0000-0001-8905-8986)
- Seung Hyeun Lee (ORCID: https://orcid.org/0000-0002-7666-313X)
- Maira Elizabeth Moreno Saavedra
- Jarosław Kołb-Sielecki
- R. Krasteva
- Sung Yong Lee (ORCID: https://orcid.org/0000-0002-8693-5792)
- Yasushi Yatabe (ORCID: https://orcid.org/0000-0003-1788-559X)
- Bhavesh Poladia
- Arya Amini
- Gudrun Absenger (ORCID: https://orcid.org/0000-0002-9788-4134)
- Qixun Chen (ORCID: https://orcid.org/0000-0003-3434-3004)
- Jingdi Wang
- Walter Weder (ORCID: https://orcid.org/0009-0008-3641-7568)
- Catherine A. Shu (ORCID: https://orcid.org/0000-0003-0765-7665)
- Kang‐Yun Lee (ORCID: https://orcid.org/0000-0003-4705-5802)
- Kaican Cai (ORCID: https://orcid.org/0000-0003-4664-6694)
- Lunxu Liu (ORCID: https://orcid.org/0000-0003-3964-5378)
- Shunichi Sugawara (ORCID: https://orcid.org/0000-0002-3427-4558)
- Touch Ativitavas
- Seong Hoon Yoon (ORCID: https://orcid.org/0000-0002-2075-4702)
- Chao Cheng (ORCID: https://orcid.org/0000-0002-5002-3417)
- Hataiwan Ratanabunjerdkul (ORCID: https://orcid.org/0009-0008-2129-2221)
- Mariano Provencio (ORCID: https://orcid.org/0000-0001-6315-7919)
- Kazuya Takamochi (ORCID: https://orcid.org/0000-0002-1721-6364)
- Nataliya Chilingirova
- Jamie E. Chaft (ORCID: https://orcid.org/0000-0002-5838-9982)
- S. Galland-Girodet
- Manoch Buranachokphaisan
- Qun Wang (ORCID: https://orcid.org/0000-0003-4853-1727)
- Chang Chen (ORCID: https://orcid.org/0000-0003-2841-1250)
- Nan Wu (ORCID: https://orcid.org/0000-0002-9939-9810)
- Wenxiang Wang (ORCID: https://orcid.org/0009-0002-9542-7746)
- Jun Zhao (ORCID: https://orcid.org/0000-0003-1464-7158)
- Shanqing Li (ORCID: https://orcid.org/0000-0003-2437-1108)
- Jianxing He (ORCID: https://orcid.org/0000-0003-1737-8192)
- Quan Lin
- Runxiang Yang (ORCID: https://orcid.org/0000-0003-3684-5892)
- Sabrina Rossi
- Nguyen Viet Nhung (ORCID: https://orcid.org/0000-0002-5447-133X)
- Lunxu Liu
- Jarin Chindaprasirt (ORCID: https://orcid.org/0000-0001-8367-0365)
- Ke‐Neng Chen
- Shobhit Baijal (ORCID: https://orcid.org/0000-0002-5842-6886)
- Mai Thi Chi Tran (ORCID: https://orcid.org/0000-0001-9315-0136)
- Vinh Vu
- M. Dómine Gómez
- Domenico Galetta (ORCID: https://orcid.org/0000-0003-4040-7211)
- Norihiko Ikeda (ORCID: https://orcid.org/0000-0002-5141-8808)
- Kang-Yun Lee
- Morihito Okada (ORCID: https://orcid.org/0000-0002-0601-3828)
- Han-Pin Kuo
- Wolfgang Schütte
- Anupriya Dayal
- Silvia Novello
- Xiangning Huang
- Jerónimo Rodríguez Cid
- Carlos Henrique Andrade Teixeira (ORCID: https://orcid.org/0000-0001-8973-5625)
- Frank Griesinger
- Sanja Dacic
- Yong Han
- Gee Chen Chang
- José Elias Miziara
- Georgia Fiuza Alencar Araripe
- Nguyen Hoang Gia
- Wei Dong Zhang (ORCID: https://orcid.org/0000-0002-8850-5235)
- Tatiana Kleimenteva
- Collin M. Blakley
- Duan Hongbing
Institutions
- AstraZeneca (United Kingdom) (GB)
- Memorial Sloan Kettering Cancer Center (US)
- University of Liverpool (GB)
- Vietnam National University, Hanoi (VN)
- University of California, San Francisco (US)
- Peking University (CN)
- University of Zurich (CH)
- Cornell University (US)
- Sichuan University (CN)
- Korea University Medical Center (KR)
- Clatterbridge Cancer Centre NHS Foundation Trust (GB)
- Kanagawa Prefectural Hospital Organization (JP)
- Yale University (US)
- West China Hospital of Sichuan University (CN)
- Peking University Cancer Hospital (CN)
- Hospital Alemão Oswaldo Cruz (BR)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Shandong Tumor Hospital (CN)
- AstraZeneca (Netherlands) (NL)
- AstraZeneca (Singapore) (SG)
- Sichuan Cancer Hospital (CN)
- Vall d'Hebron Hospital Universitari (ES)
- National Taiwan University Hospital (TW)
- AstraZeneca (Poland) (PL)
- National Cancer Center Hospital East (JP)
- Ministry of Education (ET)
- Pusan National University Yangsan Hospital (KR)
- AstraZeneca (Spain) (ES)
- State Key Laboratory of Respiratory Disease (CN)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Hanoi Lung Hospital (VN)
- Karl Landsteiner Society (AT)
- Shandong First Medical University (CN)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Vall d'Hebron Institute of Oncology (ES)
- Chiang Mai University (TH)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1200/jco-25-00883
- Citations
- 40
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 60.73