Can serum neuropeptide levels help diagnose pediatric migraine? A prospective case–control study
The present study revealed elevated VIP levels during the ictal period and elevated CGRP levels during the interictal period in patients with migraine without aura when compared to controls. In addition, VIP serum levels were significantly higher in the ictal period compared to both the interictal period and healthy controls. The findings of our study lend support to the use of these neuropeptides as biomarkers for migraine. Nevertheless, further studies and standardization are necessary to ascertain the diagnostic value of single or combinations of SP, PACAP-38, VIP, and CGRP neuropeptides in diagnosing pediatric migraine and differentiating pediatric migraine from non-migraine headaches.
Authors
- Beyhan Cengiz Özyurt (ORCID: https://orcid.org/0000-0001-5377-4593)
- Fatma Taneli (ORCID: https://orcid.org/0000-0002-5194-0460)
- Sibğatullah Ali Orak (ORCID: https://orcid.org/0000-0002-1955-5431)
- Michael D. Pak
- Muzaffer Polat (ORCID: https://orcid.org/0000-0002-1291-6417)
- Çisil Çerçi Kubur (ORCID: https://orcid.org/0000-0002-1822-3777)
- Celil Yılmaz (ORCID: https://orcid.org/0000-0002-0951-8258)
- Aslı Kübra Atasever (ORCID: https://orcid.org/0000-0003-2608-0443)
- Ahmet Angin (ORCID: https://orcid.org/0000-0003-2933-2183)
Institutions
- Manisa Celal Bayar University (TR)
- Manisa Celal Bayar Üniversitesi Hafsa Sultan Hastanesi (TR)
Publication Details
- Journal
- Headache The Journal of Head and Face Pain
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1111/head.14981
- Citations
- 3
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41