Effects of berberine administration on insulin resistance, lipid profile and general health - Narrative Review

Introduction and purpose: Berberine is a bioactive substance of natural origin that can be found in various plants. It has been used in natural medicine for ages. Recent studies have shown its potency in improving insulin resistance, lipid profile, carbohydrate metabolism and overall health. It also shows promise for aiding in weight management. This review aims to summarise current evidence and research on effects mentioned above based on various studies and their findings. Materials and Methodology: A comprehensive literature search was conducted using different databases such as PubMed, Medline, Cochrane Library, Clinical Key, Springer, MDPI, Google Scholar. Studies that evaluated effects mentioned above were included. Extraction of the data was focused on key findings, dosage of berberine, duration of supplementation, study, dosing and characteristics of examined populations. Results: Evidence found suggests that berberine significantly improves insulin sensitivity. It does so by modulation of molecular pathways. Including activation of AMP-activated protein kinase( AMPK) and improvement in expression of insulin receptor. In addition berberine exhibits beneficial influence on blood pressure, lipid profile and inflammatory markers. However the differences in population characteristics and study designs can have significant importance and can’t be overlooked. Conclusions: Berberine appears to be an effective alternative for conventional treatments in managing blood glucose levels, improving lipid profile and overall health by showing lots of beneficial properties. Yet to come to such conclusions further large-scale, long- term, randomised, controlled clinical trials are needed.