Aspirin delays preterm birth in pregnancies at high risk for preterm pre‐eclampsia: evidence from randomized clinical trial in <scp>Asia</scp>
This secondary explanatory analysis found that early administration of aspirin could effectively reduce the risk of early preterm birth in women at high risk for preterm PE. While the reasons for preterm birth are often multifactorial, this study provides greater insight into the relationship between aspirin and different types of preterm birth at different gestational ages. Our findings support the hypothesis that aspirin helps to prevent preterm birth by delaying the timing of delivery, with a greater impact observed for deliveries that would have occurred at an earlier gestational age had aspirin not been administered. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Authors
- Huishu Liu (ORCID: https://orcid.org/0000-0002-1197-5343)
- Liona C. Poon (ORCID: https://orcid.org/0000-0002-3944-4130)
- Steven W. Shaw (ORCID: https://orcid.org/0000-0002-3931-7297)
- Miao Zheng (ORCID: https://orcid.org/0000-0003-3962-7209)
- Tung‐Yao Chang (ORCID: https://orcid.org/0000-0001-8217-5530)
- Noppadol Chaiyasit (ORCID: https://orcid.org/0000-0002-6541-5990)
- Long Nguyen‐Hoang (ORCID: https://orcid.org/0009-0006-6450-0241)
- Ka Chun Chong (ORCID: https://orcid.org/0000-0001-5610-1298)
- Frank Chen (ORCID: https://orcid.org/0000-0003-4707-9361)
- Ritsuko K. Pooh (ORCID: https://orcid.org/0000-0002-1527-4595)
- Daljit Singh Sahota (ORCID: https://orcid.org/0000-0002-3755-2701)
- Ioannis Papastefanou (ORCID: https://orcid.org/0000-0002-7969-1435)
- Yali Hu (ORCID: https://orcid.org/0000-0001-5475-7840)
- Akihiko Sekizawa (ORCID: https://orcid.org/0000-0003-2249-1333)
- Raden Aditya Kusuma (ORCID: https://orcid.org/0000-0002-9164-4471)
- Tongta Nanthakomon
- Suchaya Luewan (ORCID: https://orcid.org/0000-0002-4838-175X)
- Arundhati Gosavi (ORCID: https://orcid.org/0000-0002-8785-7335)
- Arihiro Shiozaki (ORCID: https://orcid.org/0000-0002-8000-6116)
- Piengbulan Yapan
- Jay Lin (ORCID: https://orcid.org/0000-0002-6376-8469)
- Diem Thi Nguyen (ORCID: https://orcid.org/0000-0002-9680-5772)
- Yu Wu
- Nikki Lee (ORCID: https://orcid.org/0000-0003-4565-1280)
- H. H. Y. Leung (ORCID: https://orcid.org/0000-0002-2733-8939)
- WC Leung
- Linh Thuy Dinh (ORCID: https://orcid.org/0009-0002-3456-7518)
- AS Aguilar
- S. L. Lau
- Ainaa Syazana Mohamad
Institutions
- Pelita Harapan University (ID)
- Thammasat University (TH)
- Siriraj Hospital (TH)
- National University of Singapore (SG)
- Chinese University of Hong Kong (HK)
- King's College London (GB)
- Mahidol University (TH)
- Kwong Wah Hospital (CN)
- University Kebangsaan Malaysia Medical Centre (MY)
- Philippine General Hospital (PH)
- King Chulalongkorn Memorial Hospital (TH)
- Chang Gung Memorial Hospital (TW)
- Kunming Children's Hospital (CN)
- Hong Kong Jockey Club (HK)
- Nanjing Drum Tower Hospital (CN)
- Prince of Wales Hospital (CN)
- HCMC Hospital of Dermato Venereology (VN)
- Osaka Nishi Clinic (JP)
- Far East University (TW)
- Pembuluh Darah Harapan Kita (ID)
- Toyama University Hospital (JP)
- Anhui Provincial Children's Hospital (CN)
- Khanh Hoa General Hospital (VN)
- Viet Duc Hospital (VN)
- SHOWA Medical University Hospital (JP)
- University of Toyama (JP)
- Chiang Mai University (TH)
- National University of Malaysia (MY)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Ultrasound in Obstetrics and Gynecology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1002/uog.29255
- Citations
- 4
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 8.23
Funders
- Roche
- Thermo Fisher Scientific
- PerkinElmer
- Chinese University of Hong Kong
- GE Healthcare