Around-the-clock noise exposure induces hippocampus apoptosis and subsequent cognitive impairment via the PI3K/SGK1/Foxo3 signaling pathway
These findings suggest that around-the-clock noise exposure induces hippocampal neuronal apoptosis, thus exacerbating cognitive impairment. This elucidates the potential role of the PI3K/SGK1/Foxo3 pathway in noise-induced neuronal damage.
Authors
- Bo Fu (ORCID: https://orcid.org/0000-0002-6584-391X)
- Pengfang Zheng
- Xiujie Gao (ORCID: https://orcid.org/0000-0003-0296-0569)
- Bo Cui (ORCID: https://orcid.org/0000-0001-6869-2523)
- Xiaojun She (ORCID: https://orcid.org/0000-0002-0880-0534)
- Yi-Ming Fu (ORCID: https://orcid.org/0009-0004-8342-7954)
- Yingwen Zhu (ORCID: https://orcid.org/0009-0006-5183-9430)
- Honglian Yang
- Kefeng Ma
Institutions
- Academy of Military Medical Sciences (CN)
- Hainan Agricultural School (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s12967-025-06501-7
- Citations
- 2
- Primary Topic
- Noise Effects and Management
- Type
- article
- Field-Weighted Citation Impact
- 6.24