Performance of the LIAISON PLEX yeast blood culture assay for identifying 16 invasive fungal pathogens in blood cultures

Bloodstream fungal infections have serious risks of illness and death. Optimal treatment requires early pathogen identification so appropriate antifungal therapy can be immediately started. Blood culture is standard for confirming fungal infection but takes several days for results and may not provide detailed pathogen information. The LIAISON PLEX Yeast Blood Culture assay quickly analyzes fungus-positive blood cultures to identify 16 pathogenic fungi, including multiple <i>Candida</i> spp. that are common causes of bloodstream infection. This study demonstrated a high degree of test accuracy and reliability in rapidly identifying the infective pathogen in blood cultures from 132 patients with demonstrated culture-positive fungal infections. Assay performance was confirmed in 829 contrived samples, whereby samples were spiked with different fungal pathogens.

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Publication Details

Journal
Journal of Clinical Microbiology
Published
2025-06-02
DOI
https://doi.org/10.1128/jcm.00362-25
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
0.00
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article

Performance of the LIAISON PLEX yeast blood culture assay for identifying 16 invasive fungal pathogens in blood cultures

Siu-Kei Chow, Janet Farhang, Paul A. Granato, Gwyn Peterson et al.
Journal of Clinical Microbiology
Antifungal resistance and susceptibility
article

Performance of the LIAISON PLEX yeast blood culture assay for identifying 16 invasive fungal pathogens in blood cultures

Siu-Kei Chow, Janet Farhang, Paul A. Granato, Gwyn Peterson, Christopher L. Emery, Neelam Dhiman, Brian Bernier
article en

Abstract

Bloodstream fungal infections have serious risks of illness and death. Optimal treatment requires early pathogen identification so appropriate antifungal therapy can be immediately started. Blood culture is standard for confirming fungal infection but takes several days for results and may not provide detailed pathogen information. The LIAISON PLEX Yeast Blood Culture assay quickly analyzes fungus-positive blood cultures to identify 16 pathogenic fungi, including multiple <i>Candida</i> spp. that are common causes of bloodstream infection. This study demonstrated a high degree of test accuracy and reliability in rapidly identifying the infective pathogen in blood cultures from 132 patients with demonstrated culture-positive fungal infections. Assay performance was confirmed in 829 contrived samples, whereby samples were spiked with different fungal pathogens.

Journal of Clinical MicrobiologyVol. 63(7)
Luminex (United States) (US), Indiana University Health (US), MultiCare Health System (US), Quest Diagnostics (United Kingdom) (GB), Indiana University – Purdue University Indianapolis (US), Quest Diagnostics (United States) (US)
Openalex Percentile: Top 84%
Antifungal resistance and susceptibility
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