Epigenetic modifications of metabolic diseases

The review introduces modern directions of clinical and experimental research on the influence of epigenetic factors in the occurrence and development of cardiometabolic diseases (CMD), in particular metabolic syndrome, cardiovascular diseases, diabetes mellitus and obesity. The aim is to familiarize yourself with scientific research devoted to studying the role of epigenetics in the diagnosis, development, and therapy of CMD. Methods. To study this topic, articles in the PubMed, Scopus, Web of Science databases were analyzed. The search was conducted by keywords and covered English-language and Ukrainian-language publications over the past 79 years. The results. The review introduces the history of epigenetic research, the main mechanisms of epigenetic modifications and their impact on the development of CMD. The influence of epigenetic factors in the early stages of the organism’s development and in the aging process is analyzed. The influence of such factors as lifestyle, nutrition, stress and others on the development of CMD is considered. Information on the development of epigenetic drugs, their possibilities and prospects is provided.