Sialylated IgG expressed in triple-negative breast cancer cells promotes cancer progression by promoting glycolysis
These findings suggest that SIA-IgG, by enhancing glycolysis and the lactate cycle, induces metabolic reprogramming and thereby promotes the development of TNBC, making it a promising target for targeted therapy in TNBC.
Authors
- Lina Wu (ORCID: https://orcid.org/0000-0003-2350-305X)
- Weiyan Xu (ORCID: https://orcid.org/0009-0004-1300-8789)
- Jing Huang (ORCID: https://orcid.org/0000-0002-0814-838X)
- Shenghua Zhang (ORCID: https://orcid.org/0000-0002-7526-3564)
- Xinmei Huang (ORCID: https://orcid.org/0009-0006-1397-2265)
- Zhimin Fan (ORCID: https://orcid.org/0000-0001-5236-7814)
- Chenyang Hu (ORCID: https://orcid.org/0009-0006-5218-4077)
- Zhu Zhu (ORCID: https://orcid.org/0009-0008-2276-5000)
- Xiaoyan Qiu (ORCID: https://orcid.org/0000-0002-7851-332X)
- Fu‐Gang Duan (ORCID: https://orcid.org/0000-0002-8419-7167)
- Xiaoning Mo
Institutions
- Jilin University (CN)
- Peking University (CN)
- Nanjing Drum Tower Hospital (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13058-025-02052-3
- Citations
- 4
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China