Transgenerational Obesity Modulation of Gut Mucosal Immunity
The prevalence of obesity in the United States has continued to increase over the past several decades. A growing concern is that transgenerational effects of obesity negatively impact physiologic functions. We showed that consumption of a high fat, high sugar "Western" diet (WD) decreased the density of both gut innate (Paneth cells) and adaptive immune cells (intraepithelial lymphocytes; IEL). We asked whether consumption of WD impacts gut mucosal immunity in the offspring. WD-mediated Paneth cell loss was reversible, whereas IEL loss was not. However, the overall composition of the fecal microbiome and response to infection were defined by the diet consumed by the progeny. Therefore, offspring from obese dams can prevent gut immunity impairment by consuming a healthy diet.
Authors
- Marie L. Laury (ORCID: https://orcid.org/0000-0002-5082-0336)
- Sujogya Kumar Panda (ORCID: https://orcid.org/0000-0003-3123-1218)
- Umang Jain (ORCID: https://orcid.org/0000-0002-0220-8230)
- Tihana Tršan (ORCID: https://orcid.org/0000-0002-7549-2885)
- Ta‐Chiang Liu (ORCID: https://orcid.org/0000-0002-2800-9360)
- Thaddeus S. Stappenbeck (ORCID: https://orcid.org/0000-0002-6023-3901)
- Marco Colonna (ORCID: https://orcid.org/0000-0001-5222-4987)
- Chen‐Ting Hung (ORCID: https://orcid.org/0000-0003-0143-8445)
- Justin Kern (ORCID: https://orcid.org/0009-0008-8219-7623)
Institutions
- Washington University in St. Louis (US)
- Cleveland Clinic Lerner College of Medicine (US)
Publication Details
- Journal
- The FASEB Journal
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1096/fj.202500542r
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases