Isolation of Noncrystalline Compounds via Adsorption on a Solid Support

Herein is described a method for the isolation of noncrystalline compounds via adsorption on a solid support. A range of compounds that present as neat oils can be isolated as free-flowing processable solids, including the direct isolation of products from crude reaction streams. This approach was successfully implemented on a multi-kilogram scale for the isolation of a linker fragment as part of an antibody-drug conjugate (ADC) program. This strategy provides a viable alternative in cases where traditional crystallization approaches prove particularly challenging or a through process is not an option.