Elevated Zinc and Potassium Levels in Renal Calculi Indicate Distinct Pathophysiological Mechanisms in Urolithiasis
The renal calculi from females had a significantly higher potassium content than those from males. This difference was not correlated with hyperkalemia or the blood potassium levels, suggesting a sex-dependent role of uromodulin in stone formation. The stones containing calcium phosphate exhibited higher zinc and potassium concentrations compared to the pure calcium oxalate stones. The increased presence of zinc and potassium in urine may accelerate the formation of calcium phosphate calculi.
Authors
- Marcin Cichocki (ORCID: https://orcid.org/0000-0002-3265-7352)
- Magdalena Gajek (ORCID: https://orcid.org/0000-0001-9383-3631)
- Piotr Kutwin (ORCID: https://orcid.org/0000-0002-6681-3982)
- Piotr Jan Wysocki (ORCID: https://orcid.org/0000-0003-4003-5278)
- Waldemar Maniukiewicz (ORCID: https://orcid.org/0000-0001-6094-0748)
- Tomasz Konecki (ORCID: https://orcid.org/0000-0003-2273-7452)
- M. I. Szynkowska (ORCID: https://orcid.org/0000-0003-1959-3849)
- Dariusz Moczulski (ORCID: https://orcid.org/0000-0002-0926-9909)
- Maciej Jaromin (ORCID: https://orcid.org/0009-0008-9825-2543)
Institutions
- Lodz University of Technology (PL)
- Medical University of Lodz (PL)
Publication Details
- Journal
- Pathophysiology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.3390/pathophysiology32020023
- Citations
- 1
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52