Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus
Diurnally fluctuating central serotonin and noradrenaline levels and/or diurnal fluctuation in choroid plexus adrenergic receptor expression may contribute to the diurnal shift in human and rodent CSF secretion rate. These signaling pathways could thus potentially be harnessed to create pharmacological modulation of the CSF secretion rate in pathological conditions of elevated ICP.
Authors
- Nanna MacAulay (ORCID: https://orcid.org/0000-0002-7800-6600)
- Annette Buur Steffensen (ORCID: https://orcid.org/0000-0003-0613-2410)
- Beatriche Louise Edelbo (ORCID: https://orcid.org/0000-0003-2294-1859)
- E. Révész
- Søren Norge Andreassen
Institutions
- University of Copenhagen (DK)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s12987-025-00666-5
- Citations
- 2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Københavns Universitet
- Lundbeckfonden