High Selective N-Acylhydrazones Silver(I) Complexes against Tuberculosis

In the present work, synthesis, characterization, and biological assays of seven N-acylhydrazones derivatives of isoniazid and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, infrared (IR) and 1 H, 13C and 1 H-15N nuclear magnetic resonance (NMR) spectroscopic measurements, and molar conductivity over 48 h assays. Density functional theory (DFT) studies also were employed in order to structural elucidation of the seven silver(I) complexes. All the synthesized silver complexes have shown minimum inhibitory concentration (MIC90) values against Mycobacterium tuberculosis - MtbH37Rv (ATCC 27294) lower than 7.421 mg L–1. The AgIZBEN complex showed the most promising anti-tuberculosis action, with MIC90 of 0.956 mg L–1 and selectivity index (SI) = 29.3 while the AgIZpAN showed SI higher than 460 and MIC90 of 1.077 mg L–1. The free acylhydrazones derivatives also showed SI higher than 20.