Comparison of NADAL COVID IgG/IgM rapid test and DiaSorin Liaison SARS-CoV-2 S1/S2 IgG assay across different blood sources and substrates

Accurate serological assays are essential for assessing population immunity levels and identifying vulnerable subgroups with lower immunity on which to focus vaccination efforts. Although rapid tests may offer the possibility of easy point-of-care testing on whole capillary blood for these purposes, they may not be as robust as other assays when used on different blood substrates or sources than those in which they were approved. The observed variability in test performance across different substrates and blood sources highlights the importance of pretesting assays under the specific conditions in which they would be used to ensure optimal interpretation of the immune status in the community.