RECENT ADVANCES IN THE SYNTHESIS ANDSTRUCTURAL ELUCIDATION OFTETRASUBSTITUTED PYRROLES UNDERSUPERBASIC CONDITION

Pyrrole derivatives are widely recognized for their presence in biologically active natural products, pharmaceuticals, and advanced functional materials.Given their significant role in systems such as heme, chlorophyll, and vitamin B, the development of efficient synthetic approaches to functionalized pyrroles remains a crucial objective in organic chemistry.In this study, we investigated a three-step synthesis of -substituted pyrrole derivatives based on aromatic-substituted 1,3-dicarbonyl compounds and 2,3-dibromoprop-1-ene.New 2phenyl tetra substituted pyrroles were synthesized in a superbasic medium comprising t-BuOK/DMSO in t-BuOH.The structure of new synthesized compounds were confirmed by 1 H and 13 C NMR spectroscopy.