Giant Breast Masses: Part II—Malignant Etiologies

Giant breast masses, arbitrarily defined as lesions 5 cm or greater in dimension, can pose significant diagnostic challenges as they may present similarly and may be incompletely evaluated by conventional modalities, given their size. Therefore, a multimodality approach may be needed for diagnostic and prognostic reasons. Benign giant breast masses were discussed in part I of this 2-part series. Here we review how malignant etiologies such as phyllodes tumors, angiosarcomas, breast lymphomas, papillary tumors, and locally advanced invasive tumors can present as giant breast masses.