Direct Deoxygenative Formylation of Ketones with Titanium
The introduction of a formyl group at the ketone position is valuable in organic synthesis, and existing methods often rely on multistep procedures and strong bases. Herein, we report a direct deoxygenative formylation of ketones, enabled by a newly developed, cost-effective titanium reagent, (<sup><i>i</i></sup>PrO)<sub>2</sub>Ti(bpy)Cl<sub>2</sub>. This readily accessible reagent demonstrates high selectivity for ketone-DMF coupling, effectively suppressing traditional carbonyl coupling between ketones and/or aldehydes. This method provides a base-free alternative for converting diverse ketones into aldehydes.
Authors
- Xing‐Zhong Shu (ORCID: https://orcid.org/0000-0002-0961-1508)
- Yuquan Wang (ORCID: https://orcid.org/0009-0001-0713-3354)
Institutions
- Lanzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1021/acs.orglett.5c01624
- Citations
- 5
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Natural Science Foundation of China
- Science and Technology Department of Gansu Province
- Fundamental Research Funds for the Central Universities