Aztreonam plus ceftazidime-avibactam for post-neurosurgical meningitis due to <i>Stenotrophomonas maltophilia</i>
Clinical evidence is lacking regarding the efficacy of aztreonam-avibactam in severe infections involving <i>Stenotrophomonas maltophilia</i>. We report a case of post-neurosurgical meningitis due to <i>S. maltophilia</i> (minimal inhibitory concentration of aztreonam plus avibactam, 4/4 µg/mL) clinically and microbiologically cured with a combination of aztreonam and ceftazidime-avibactam (2 g and 2 g/500 mg q8h, 3 h simultaneous infusions). Therapeutic drug monitoring showed adequate concentrations of aztreonam and avibactam in the cerebrospinal fluid at each time point over the 14-day treatment duration.
Authors
- Thierry Boulain (ORCID: https://orcid.org/0000-0003-4664-3661)
- Étienne Carbonnelle (ORCID: https://orcid.org/0000-0003-4354-5900)
- Vincent Jullien (ORCID: https://orcid.org/0000-0002-5971-6316)
- Sophie Magréault (ORCID: https://orcid.org/0000-0003-4786-3965)
- François Barbier (ORCID: https://orcid.org/0000-0002-8447-7265)
- Maxime Desgrouas (ORCID: https://orcid.org/0000-0002-7713-2293)
- Jonathan Wong-So
Institutions
- Inserm (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Nord University (NO)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre hospitalier universitaire d'Orléans (FR)
- Hôpital Jean-Verdier (FR)
Publication Details
- Journal
- Antimicrobial Agents and Chemotherapy
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1128/aac.00172-25
- Citations
- 3
- Primary Topic
- Infections and bacterial resistance
- Type
- article
- Field-Weighted Citation Impact
- 5.39