Anti-VEGF Agents Clearance Through the Aqueous Outflow Pathway in a Rat Model
Bevacizumab, aflibercept, and ranibizumab cleared completely from the iridocorneal angle at 48 hours in the brown Norway rats following a single intravitreal injection and with similar a clearance rate. These findings support our earlier studies refuting the anti-VEGF aggregation hypothesis.
Authors
- I Spector
- Assaf Dotan
- Assaf Ben-Arzi
- Orly Gal‐Or (ORCID: https://orcid.org/0000-0002-3421-4555)
- Irit Bahar (ORCID: https://orcid.org/0000-0003-2008-0717)
- Yariv Keshet (ORCID: https://orcid.org/0000-0003-1424-4295)
Institutions
- Tel Aviv University (IL)
- Rabin Medical Center (IL)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1167/iovs.66.6.1
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tel Aviv University