Addressing the Global Challenge of Nitrous Oxide Misuse Through a Multidisciplinary Approach: Example of the PROTOSIDE Network
Nitrous oxide (N<sub>2</sub>O) was originally used for medical and industrial purposes, but its recreational use has dramatically increased, raising a major global public health concern. Chronic inhalation is associated with neurological, metabolic, and psychiatric complications, as well as addiction. To address these challenges, the PROTOSIDE network was developed to provide a multidisciplinary approach to management and prevention. This initiative relies on competence centers integrating specialists in emergency medicine, neurology, clinical biochemistry, and addiction medicine. PROTOSIDE aims to standardize diagnostic protocols, optimize patient care pathways, and strengthen addictovigilance. A strong emphasis is placed on prevention, including awareness campaigns and collaboration with healthcare professionals and educators. By facilitating access to advanced biochemical analyses (homocysteine, methylmalonic acid) and promoting international guidelines, PROTOSIDE represents an innovative model for a global response to N<sub>2</sub>O misuse. This integrated approach enhances clinical management, reduces complications, and harmonizes public health strategies.
Authors
- Benjamin Rolland (ORCID: https://orcid.org/0000-0002-8666-3635)
- Rémy Diesnis (ORCID: https://orcid.org/0000-0001-7938-4091)
- Guillaume Grzych (ORCID: https://orcid.org/0000-0003-2813-0109)
- Catherine Riou (ORCID: https://orcid.org/0000-0001-9679-0745)
- Anthony Chauvin (ORCID: https://orcid.org/0000-0001-8819-0061)
- Jean Claude Guichard
- Émeline Gernez (ORCID: https://orcid.org/0009-0006-3180-322X)
- Bruno Mégarbane (ORCID: https://orcid.org/0000-0002-2522-2764)
- Thierry Dupré (ORCID: https://orcid.org/0000-0003-3081-944X)
- Anas Bennis
- Sylvie Deheul
- Étienne Cavalier (ORCID: https://orcid.org/0000-0003-0947-2226)
- Damien Denimal (ORCID: https://orcid.org/0000-0001-5454-954X)
- Laurent Karila (ORCID: https://orcid.org/0000-0001-7061-4954)
- Isabelle Redonnet‐Vernhet (ORCID: https://orcid.org/0000-0002-5102-3814)
- Cécile Bossaert
- Damien Scliffet (ORCID: https://orcid.org/0000-0003-0761-3654)
- Alexandra Boucher
- Jean Paul Niguet
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of Liège (BE)
- Université Paris Cité (FR)
- Université de Lille (FR)
- Université Paris-Saclay (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Centre Hospitalier de Roubaix (FR)
- Centre de Recherche en Neurosciences de Lyon (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospices Civils de Lyon (FR)
- Centre Hospitalier de Lens (FR)
- Hôpital Lariboisière (FR)
- Centre Hospitalier Le Vinatier (FR)
- Groupe Hospitalier de l'Institut Catholique de Lille (FR)
- Centre de recherche Translationnelle en Médecine moléculaire (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Bicêtre Hospital (FR)
- Hôpital Saint-Vincent-de-Paul (FR)
- Institut de Biologie de Lille (FR)
- Hôpital Paul-Brousse (FR)
- Maladies Rares: Génétique et Métabolisme (FR)
Publication Details
- Journal
- Toxics
- Published
- 2025-05-31
- DOI
- https://doi.org/10.3390/toxics13060466
- Citations
- 3
- Primary Topic
- Prenatal Substance Exposure Effects
- Type
- article
- Field-Weighted Citation Impact
- 10.48