Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

Overall, our results suggest that inflammation-induced metabolic reprogramming places lysosomes under substantial stress. Lysosomal stress is more detrimental in APOE4/4 microglia, which exhibit endo-lysosomal defects.

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Publication Details

Journal
Journal of Neuroinflammation
Published
2025-06-02
DOI
https://doi.org/10.1186/s12974-025-03470-y
Citations
9
Primary Topic
Autophagy in Disease and Therapy
Type
article
Field-Weighted Citation Impact
12.19

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article

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

Marianna Hellén, Mari Takalo, Michael Peitz, Marja Koskuvi et al.
9 citations
Journal of Neuroinflammation
Autophagy in Disease and Therapy
12.19
article

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

Marianna Hellén, Mari Takalo, Michael Peitz, Marja Koskuvi, Pinja Kettunen, Alfredo Ramı́rez, Ville Leinonen, Klaus Fließbach, Taisia Rõlova, Olli K. Kärkkäinen, Jari Koıstınaho, Stefan F. Lichtenthaler, Šárka Lehtonen, Stephan A. Müller, Noora Räsänen, Isabelle Weert, Mikko Hiltunen
article en
9 citations

Abstract

Overall, our results suggest that inflammation-induced metabolic reprogramming places lysosomes under substantial stress. Lysosomal stress is more detrimental in APOE4/4 microglia, which exhibit endo-lysosomal defects.

Journal of NeuroinflammationVol. 22(1)
University of Helsinki (FI), University of Bonn (DE), The University of Texas at San Antonio Health Science Center (US), University of Eastern Finland (FI), University of Cologne (DE), University Hospital Bonn (DE), German Center for Neurodegenerative Diseases (DE), TUM Klinikum (DE), Kuopio University Hospital (FI), Institute for Neurodegenerative Disorders (US), Munich Cluster for Systems Neurology (DE), Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE), Delfin Technologies (Finland) (FI), Technical University of Munich (DE)
Itä-Suomen Yliopisto, Helsingin Yliopisto, Biocenter Finland, Helsinki Institute of Life Science, Helsingin Yliopisto
Good health and well-being
Openalex Percentile: Top 1%
Autophagy in Disease and Therapy
12.19
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