Causal association of cholesterol metabolism-related proteins with hepatocellular carcinoma and dysfunction-associated steatotic liver disease: a mendelian randomization study
Our findings delineate a novel mechanistic involvement of cholesterol regulatory proteins, with APOE demonstrating pathogenic significance in both HCC and MASLD. This investigation substantially provides new insights into the molecular mechanisms of these liver diseases and highlights potential therapeutic targets.
Authors
- Dianzhe Tian (ORCID: https://orcid.org/0009-0006-3618-9054)
- Lei Zhang (ORCID: https://orcid.org/0009-0008-9783-092X)
- Han Zheng (ORCID: https://orcid.org/0000-0003-4032-4299)
- Shitao Jiang (ORCID: https://orcid.org/0000-0001-7298-0237)
- Yiyao Xu
- Xin Lu (ORCID: https://orcid.org/0000-0002-4951-6134)
- Yaoge Liu (ORCID: https://orcid.org/0000-0002-2844-5306)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1007/s12672-025-02321-9
- Citations
- 2
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Peking Union Medical College Hospital