Neurologic and Psychological Outcomes 2 Years After Multisystem Inflammatory Syndrome in Children
In this longitudinal, matched cohort study of children with MIS-C and controls followed up sequentially up to 2 years after hospital discharge, children with MIS-C had more somatic symptoms than control children. Overall, however, patients with MIS-C had improved neurologic and psychological outcomes between the testing intervals, performing similarly to controls on most measures by year 2 follow-up. These findings suggest that these concerns may improve over time.
Authors
- Johanna Calderon (ORCID: https://orcid.org/0000-0002-2644-6858)
- Margaret M. Newhams (ORCID: https://orcid.org/0000-0002-3738-1172)
- Caitlin K. Rollins (ORCID: https://orcid.org/0000-0002-0500-0056)
- Mary Beth F. Son (ORCID: https://orcid.org/0000-0002-7394-2862)
- Jennifer L. McGuire (ORCID: https://orcid.org/0000-0002-8245-7199)
- David Wypij (ORCID: https://orcid.org/0000-0001-8367-8711)
- Moshe Maiman
- Lael M. Yonker (ORCID: https://orcid.org/0000-0003-1711-8227)
- Charlotte V. Hobbs (ORCID: https://orcid.org/0000-0003-4829-0791)
- Meghan Murdock
- Lora Martin (ORCID: https://orcid.org/0009-0000-7750-8468)
- Paul Licht
- Joe Kossowsky (ORCID: https://orcid.org/0000-0002-6272-6259)
- Maitreyi Mazumdar (ORCID: https://orcid.org/0000-0003-0380-2407)
- Aline B. Maddux (ORCID: https://orcid.org/0000-0002-0949-4284)
- Jane W. Newburger (ORCID: https://orcid.org/0000-0002-7794-9017)
- Mary Allen Staat (ORCID: https://orcid.org/0000-0003-1788-8037)
- Nicholas Hart (ORCID: https://orcid.org/0000-0002-6863-585X)
- Laura D. Zambrano (ORCID: https://orcid.org/0000-0002-0145-9142)
- Matthew L. Friedman (ORCID: https://orcid.org/0000-0001-8562-2914)
- Adrienne G. Randolph (ORCID: https://orcid.org/0000-0002-3084-3071)
- Heather Kelly (ORCID: https://orcid.org/0000-0001-9936-5242)
- S. Fernando Rodriguez
- Michele Kong (ORCID: https://orcid.org/0000-0001-6596-3965)
- Jennifer Worhach (ORCID: https://orcid.org/0000-0002-5254-2894)
- Candice Colston (ORCID: https://orcid.org/0000-0003-1198-0027)
- Lacy Malloch (ORCID: https://orcid.org/0000-0001-9523-1706)
- Angela P. Campbell (ORCID: https://orcid.org/0000-0002-2576-482X)
- Ashley Stanley-Copeland
- Alex M. Taylor
- Jeanie Craft
- Tina Pouissaint
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- Centers for Disease Control and Prevention (US)
- Children's Hospital of Philadelphia (US)
- Harvard University (US)
- Inserm (FR)
- National Center for Immunization and Respiratory Diseases (US)
- Riley Hospital for Children (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- University of Alabama at Birmingham (US)
- Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR)
- Massachusetts General Hospital (US)
- Children's Hospital Colorado (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Cincinnati (US)
- University of Pennsylvania (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.12487
- Citations
- 2
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Centers for Disease Control and Prevention