Interleukin-22 as a novel therapy for trauma relevant acute kidney injury
IL-22:Fc protects the kidneys after H/R and appears to act selectively on the outer medulla. This beneficial effect does not appear to be mediated by signal transducer and activator of transcription 3, as shown in other organ systems. IL-22:Fc may be a novel therapy for AKI in trauma patients.
Authors
- Farzana Shaheen (ORCID: https://orcid.org/0000-0003-0057-3960)
- John Henry Dasinger (ORCID: https://orcid.org/0000-0001-6667-0427)
- David Engelhardt (ORCID: https://orcid.org/0009-0005-1026-2869)
- Sharven Taghavi (ORCID: https://orcid.org/0000-0001-6289-2129)
- C. Mills (ORCID: https://orcid.org/0000-0003-4329-1875)
- Allison Newell
- Jay K. Kolls (ORCID: https://orcid.org/0000-0001-5151-6304)
- Olan Jackson‐Weaver (ORCID: https://orcid.org/0000-0002-0545-0647)
- Heddwen L. Brooks (ORCID: https://orcid.org/0000-0002-4589-1738)
Institutions
- Tulane University (US)
- Fundación Juan March (ES)
- Apple (Israel) (IL)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1097/ta.0000000000004655
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81