Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement
In patients with GPA or MPA with kidney involvement, treatment with an avacopan regimen compared with a prednisone taper regimen achieved similar rates of remission, improved recovery of kidney function, led to faster reduction in albuminuria and hematuria, and lowered GC-related toxicity, with an acceptable safety profile.
Authors
- N. Ogawa
- G. Luxton
- Rafik Mesbah (ORCID: https://orcid.org/0000-0001-6859-4851)
- Talha Shahid Amin
- Yoriaki Kaneko (ORCID: https://orcid.org/0000-0003-4567-6082)
- Dana Kidder (ORCID: https://orcid.org/0000-0002-2001-3998)
- A. Nandagudi
- Tom H. Lindner
- A. Kivitz
- R. Hellemans
- William Julius Shergy
- Nils Venhoff (ORCID: https://orcid.org/0000-0001-7729-2759)
- Vicki Levidiotis
- Robert Spiera (ORCID: https://orcid.org/0000-0003-2911-6800)
- Matthias Schaier (ORCID: https://orcid.org/0000-0003-1040-1150)
- Alan David Salama (ORCID: https://orcid.org/0000-0002-9255-9092)
- Yohei Kirino (ORCID: https://orcid.org/0000-0002-9488-661X)
- Georges Nakhoul (ORCID: https://orcid.org/0000-0002-8997-1940)
- Nathalie Demoulin (ORCID: https://orcid.org/0000-0002-3566-3950)
- Jocelyn Taylor (ORCID: https://orcid.org/0000-0003-3441-2065)
- Thomas Daikeler
- Andreas Kronbichler (ORCID: https://orcid.org/0000-0002-2945-2946)
- Divi Cornec (ORCID: https://orcid.org/0000-0002-9159-702X)
- A. Ritchie
- H. Mehling
- M. Robson
- R. Obi
- T. Mimura
- Armelle Klein (ORCID: https://orcid.org/0000-0001-5749-3529)
- Jeanette S. Andrews
- Simon J. Griffin (ORCID: https://orcid.org/0000-0002-2157-4797)
- Sarah Bray (ORCID: https://orcid.org/0000-0002-4867-574X)
- Giacomo Garibotto (ORCID: https://orcid.org/0000-0001-6432-2429)
- Peter F. Mount (ORCID: https://orcid.org/0000-0001-7637-3661)
- Patrick E. Gipson
- Dario Roccatello (ORCID: https://orcid.org/0000-0002-4419-6813)
- Rainer Klocke
- Ulrich Specks (ORCID: https://orcid.org/0000-0002-6559-1206)
- Jörg Henes (ORCID: https://orcid.org/0000-0002-8385-6861)
- Marwan Omar Kaskas
- Salvatore De Vita (ORCID: https://orcid.org/0009-0004-3623-4674)
- Michael Walsh (ORCID: https://orcid.org/0000-0001-8292-2014)
- Lucio Manenti (ORCID: https://orcid.org/0000-0002-4144-2142)
- Jan Halbritter (ORCID: https://orcid.org/0000-0002-1377-9880)
- Irene Agraz Pamplona
- James O. Burton (ORCID: https://orcid.org/0000-0003-1176-7592)
- Shinya Kaname (ORCID: https://orcid.org/0000-0002-9507-180X)
- Ben Sprangers (ORCID: https://orcid.org/0000-0003-1314-9675)
- Annette Bruchfeld (ORCID: https://orcid.org/0000-0002-9752-9941)
- Carol A. Langford (ORCID: https://orcid.org/0000-0001-9498-321X)
- Raashid Luqmani (ORCID: https://orcid.org/0000-0002-4446-5841)
- John L. Niles (ORCID: https://orcid.org/0009-0003-4072-6535)
- Noémie Jourde‐Chiche (ORCID: https://orcid.org/0000-0001-9315-1577)
- Hiroaki Dobashi (ORCID: https://orcid.org/0000-0003-2944-5583)
- Gregory Todd Greenwood
- S. Dragoi
- Andrew S. Bomback (ORCID: https://orcid.org/0000-0001-5449-1667)
- Xavier Fulladosa (ORCID: https://orcid.org/0000-0003-1974-9874)
- Helena Marco Rusinol
- Montserrat M. Díaz Encarnación (ORCID: https://orcid.org/0000-0001-5172-3370)
- Jean‐Michel Hougardy (ORCID: https://orcid.org/0000-0002-7769-5360)
- Torsten Kubacki (ORCID: https://orcid.org/0000-0001-7723-9659)
- Alexandre Karras (ORCID: https://orcid.org/0000-0002-3075-7739)
- Jordi Antón (ORCID: https://orcid.org/0000-0002-8792-4219)
- Richard Jimenez (ORCID: https://orcid.org/0000-0001-9990-404X)
- C. Hugo
- Aron Chakera (ORCID: https://orcid.org/0000-0003-3369-4187)
- F. Maurier (ORCID: https://orcid.org/0000-0002-3222-8566)
- Lorenzo Dagna (ORCID: https://orcid.org/0000-0002-7428-315X)
- Mårten Segelmark (ORCID: https://orcid.org/0000-0002-1221-0772)
- Inga Soveri (ORCID: https://orcid.org/0000-0001-6710-6422)
- Eiji Sugiyama (ORCID: https://orcid.org/0000-0001-8534-6729)
- Kiyoki Kitagawa (ORCID: https://orcid.org/0000-0003-1569-7368)
- Robert Walker (ORCID: https://orcid.org/0000-0003-3366-0956)
- Christopher Charles Striebich
- G. Marder
- R. Rajakariar
- Dia Rose Waguespack (ORCID: https://orcid.org/0009-0006-0494-8044)
- Matthias H. Busch (ORCID: https://orcid.org/0000-0001-7324-2471)
- Christof Iking‐Konert (ORCID: https://orcid.org/0000-0002-8716-3894)
- Lorraine Harper (ORCID: https://orcid.org/0000-0003-1343-9234)
- Edmond O’Riordan (ORCID: https://orcid.org/0000-0002-3607-2589)
- Peter Lamprecht (ORCID: https://orcid.org/0000-0001-5929-868X)
- Abdulfataah A A Mohamed (ORCID: https://orcid.org/0009-0005-4145-0459)
- Tanaz A. Kermani (ORCID: https://orcid.org/0000-0002-7335-7321)
- Mumtaz Patel (ORCID: https://orcid.org/0000-0001-7016-819X)
- Ryutaro Matsumura (ORCID: https://orcid.org/0000-0002-6644-243X)
- V. Barrio Lucia
- Patrick Liang (ORCID: https://orcid.org/0000-0003-0089-5337)
- R. Gohh
- Joanna Robson (ORCID: https://orcid.org/0000-0002-7939-5978)
- I. Chua
- Taio Naniwa (ORCID: https://orcid.org/0000-0002-0489-2611)
- M. Cinta Cid
- Lucy Smyth (ORCID: https://orcid.org/0000-0001-6814-4877)
- Dwarakanathan Ranganathan (ORCID: https://orcid.org/0000-0003-1215-1773)
- C. Bovy
- Brad H. Rovin (ORCID: https://orcid.org/0000-0001-5639-0210)
- Louis‐Philippe Laurin (ORCID: https://orcid.org/0000-0003-1598-5562)
- Tohru Takeuchi (ORCID: https://orcid.org/0000-0002-0065-929X)
- Ken‐ei Sada (ORCID: https://orcid.org/0000-0003-1020-0818)
- Alexandre Bélot (ORCID: https://orcid.org/0000-0003-4902-5332)
- Atsushi Ihata
- Maria K Eriksson Svensson (ORCID: https://orcid.org/0000-0001-7545-5585)
- Thomas Häuser (ORCID: https://orcid.org/0000-0003-1170-6749)
- CD Pusey
- G Szücs
- Ina Kötter (ORCID: https://orcid.org/0000-0002-9262-005X)
- Luis Quintana Porras
- J. Dudler
- S. Barbour
- Yohko Murakawa (ORCID: https://orcid.org/0000-0002-7122-4832)
- J. Carlin
- Federico Alberici (ORCID: https://orcid.org/0000-0002-1686-5709)
- Manuel Praga (ORCID: https://orcid.org/0000-0001-9270-1071)
- Bruno Vogt (ORCID: https://orcid.org/0000-0002-1548-6387)
- Noboru Hagino (ORCID: https://orcid.org/0000-0003-3053-5682)
- Oliver Floßmann (ORCID: https://orcid.org/0000-0001-5976-3609)
- M. Ficheux
- Thomas Neumann (ORCID: https://orcid.org/0000-0003-3755-9038)
- Synove Kalstad
- Fabian Arndt
- Daman Langguth (ORCID: https://orcid.org/0000-0002-5706-2347)
- Frank B. Cortazar (ORCID: https://orcid.org/0000-0003-4532-5039)
- Duvuru Geetha (ORCID: https://orcid.org/0000-0001-8353-5542)
- Chen Au Peh (ORCID: https://orcid.org/0000-0002-9712-0396)
- Curry L. Koening (ORCID: https://orcid.org/0000-0002-4494-7672)
- David W. Mudge (ORCID: https://orcid.org/0000-0002-4112-5550)
- A. Katagiri
- Paul A. Brogan (ORCID: https://orcid.org/0000-0001-6178-6893)
- J Sznajd
- Patricia Paris
- Peter Lanyon (ORCID: https://orcid.org/0000-0002-9855-6802)
- Marion Haubitz
- Jessica Ryan (ORCID: https://orcid.org/0000-0003-2007-6021)
- Bhaskar Dasgupta (ORCID: https://orcid.org/0000-0002-5523-6534)
- István Szombati
- Antoine G. Sreih (ORCID: https://orcid.org/0000-0002-7864-0185)
- K. Rabindranath
- L. McCann
- Naoto Tamura (ORCID: https://orcid.org/0000-0003-1729-2954)
- Atsushi Komatsuda (ORCID: https://orcid.org/0000-0003-1477-8131)
- Federico Pieruzzi (ORCID: https://orcid.org/0000-0002-1302-6846)
- Abraham Rutgers (ORCID: https://orcid.org/0000-0002-1641-6890)
- Shoichi Fujimoto
- K. Lhotta
- Giacomo Emmi (ORCID: https://orcid.org/0000-0001-9575-8321)
- Kerstin Westman (ORCID: https://orcid.org/0000-0002-2930-998X)
- Hajime Kono (ORCID: https://orcid.org/0000-0002-4578-8677)
- A. Swarup
- Reem Al Jayyousi
- Alejandra Tellez Silva
- Ulf Schönermarck (ORCID: https://orcid.org/0000-0002-3266-9791)
- David Jayne (ORCID: https://orcid.org/0000-0002-1712-0637)
- Michel Burnier (ORCID: https://orcid.org/0000-0003-1283-8487)
- Louis Girard (ORCID: https://orcid.org/0000-0002-9044-008X)
- María José Soler (ORCID: https://orcid.org/0000-0003-3621-0766)
- Bruce A. Cooper (ORCID: https://orcid.org/0000-0001-8932-4113)
- R. Phoon
- M. Chester Wasko
- Reysha Patel (ORCID: https://orcid.org/0000-0003-2379-6665)
- Enrico Brunetta (ORCID: https://orcid.org/0000-0002-0676-1228)
- Janice Marian Harper
- Franziska Grundmann (ORCID: https://orcid.org/0000-0002-5766-7477)
- Akio Morinobu (ORCID: https://orcid.org/0000-0002-4672-638X)
- Philippe Zaoui (ORCID: https://orcid.org/0000-0001-5332-1586)
- Eleanor J. Molloy (ORCID: https://orcid.org/0000-0001-6798-2158)
- Christian Pagnoux (ORCID: https://orcid.org/0000-0001-6287-9549)
- Vimal K. Derebail (ORCID: https://orcid.org/0000-0002-7662-7497)
- P. van Daele
- Urs Benck
- Yih Chang Lin
- N. Roxanne Neyra
- Lindsy Forbess
- Tatsuo Tsukamoto (ORCID: https://orcid.org/0000-0003-2896-5595)
- R. Sam
- M. Suranyi
- L. Baines
- S. Cournoyer
- Tatsuya Atsumi (ORCID: https://orcid.org/0000-0001-5657-962X)
- Eleni Thomaidi
- Kunihiro Yamagata (ORCID: https://orcid.org/0000-0002-7407-0410)
- H. Oshima
- Michael P. Collins (ORCID: https://orcid.org/0000-0002-9661-145X)
- S. Thakar
- Claire Rigothier (ORCID: https://orcid.org/0000-0002-5569-5562)
- Toshihiro Nanki (ORCID: https://orcid.org/0000-0002-3482-074X)
- Y K Onno Teng (ORCID: https://orcid.org/0000-0001-9920-2195)
- Gregory W. Niemer
- David Makanjuola (ORCID: https://orcid.org/0000-0001-9064-9433)
- Paul A. Monach (ORCID: https://orcid.org/0000-0003-4937-0515)
- S. Selvan
- Raoul Bergner (ORCID: https://orcid.org/0000-0002-7965-1273)
- Anisha B. Dua (ORCID: https://orcid.org/0000-0002-3508-9290)
- E. Belilos
- David Saadoun (ORCID: https://orcid.org/0000-0003-3628-9996)
- S. Hugenberg
- Janak de Zoysa (ORCID: https://orcid.org/0000-0001-7528-9230)
- Bernd Hohenstein (ORCID: https://orcid.org/0000-0002-7306-3825)
- Oliver Witzke (ORCID: https://orcid.org/0000-0002-1019-1301)
- David Philibert
- Olivier Moranne (ORCID: https://orcid.org/0000-0002-3127-1415)
- Jadadeesh Kurtkoti
- H. Taki
- H. Seeger
- Jason Springer (ORCID: https://orcid.org/0000-0002-3903-6049)
- Volker Vielhauer (ORCID: https://orcid.org/0000-0001-8187-3783)
- Mark A. Little (ORCID: https://orcid.org/0000-0001-6003-397X)
- B. Hellmich
- Soumeya Brachemi
- A. Tiliakos
- Jean‐François Augusto (ORCID: https://orcid.org/0000-0003-1498-2132)
- Yi‐Shan Tsai (ORCID: https://orcid.org/0000-0002-0898-9250)
- Secundino Ciggaran
- Armando Gabrielli (ORCID: https://orcid.org/0000-0003-3189-5516)
- Benjamin Terrier (ORCID: https://orcid.org/0000-0001-6612-7336)
- Carlo Salvarani (ORCID: https://orcid.org/0000-0003-3708-3148)
- Masayuki Yamamura (ORCID: https://orcid.org/0000-0001-6113-3796)
- Peter A. Merkel (ORCID: https://orcid.org/0000-0001-9284-7345)
- Dominique Chauveau
- T. Quéméneur
- Jürgen Floege (ORCID: https://orcid.org/0000-0001-7102-6150)
- Alexander R. Rosenkranz (ORCID: https://orcid.org/0000-0003-4838-2944)
- Bård Waldum - Grevbo
- Timothy William Ronald Doulton
- Peter A. Merkel
- Hermann Haller
- Takahiko Kurasawa
- Michihito Katayama
- Katherine D. Wissing
- Euan Noble
- Michael Clarkson
- D. Parks
- Amber S. Podoll
- John McLaren
- Charles Owens
- A. Segarra
- Antoine Néel (ORCID: https://orcid.org/0000-0002-7707-5794)
- Alana M. Bozeman
Institutions
- Linköping University (SE)
- Cleveland Clinic (US)
- Amgen (United States) (US)
- Karolinska University Hospital (SE)
- Innsbruck Medical University (AT)
- Johns Hopkins University (US)
- Université Paris Cité (FR)
- University of Cambridge (GB)
- Johns Hopkins Medicine (US)
- Karolinska Institutet (SE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- University of Pennsylvania (US)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.ekir.2025.05.041
- Citations
- 3
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- American Society of Nephrology
- Amgen