Bradykinin measurement by liquid chromatography tandem mass spectrometry in subjects with hereditary angioedema enhanced by cold activation
Whole blood under cold activation showed striking elevation of BK levels in subjects with HAE-C1INH, while minimally affecting healthy volunteers. The assay has been assessed for accuracy, precision and stability. It may serve as a reliable tool for HAE diagnosis and management.
Authors
- Yunkou Wu
- Lili Wan (ORCID: https://orcid.org/0000-0002-9520-5425)
- J Joanna Yu
- Mark Scarupa
- Joseph Chiao
- Jing Yu (ORCID: https://orcid.org/0000-0002-8694-8948)
- Henry Li (ORCID: https://orcid.org/0000-0001-5587-968X)
- Jinguo Chen (ORCID: https://orcid.org/0000-0002-8154-0994)
Institutions
- Institute for Asthma and Allergy (US)
- Wheaton College - Illinois (US)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.jacig.2025.100505
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.00