Single-nucleus RNA sequencing reveals Cntnap2+ astrocytes triggering a hypertensive effect in the rostral ventrolateral medulla by disrupting glutamate uptake
Our findings suggest that Cntnap2 may impede glutamate homeostasis at least partially through regulating Eaat2 in astrocytes, which could consequently enhance RVLM neuronal excitability, increase sympathetic tone, and contribute to elevated BP.
Authors
- Dongshu Du (ORCID: https://orcid.org/0000-0003-1198-1089)
- Liucun Zhu (ORCID: https://orcid.org/0000-0002-8334-0216)
- Shuai Zhang (ORCID: https://orcid.org/0000-0002-5662-4758)
- Ding Zhu (ORCID: https://orcid.org/0000-0002-7924-6948)
- Linping Wang
- Haisheng Liu (ORCID: https://orcid.org/0000-0002-7815-7409)
- Dong Huang
- Lei Tong (ORCID: https://orcid.org/0000-0001-5391-9553)
- Zhangyan Ren
- Tengteng Dai
Institutions
- Shanghai University (CN)
- Zhejiang Chinese Medical University (CN)
- Shaoxing University (CN)
- Heze University (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.jare.2025.06.002
- Citations
- 2
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province