Characterization of multidrug resistance in clinical Klebsiella pneumoniae strains carrying drug efflux pumps and multiple repetitive tandem blaKPC-2 core structures
The evolution of these strains is intricately linked to the core structures of bla<sub>KPC-2</sub> and/or bla<sub>CTX-M-65</sub>. Moreover, the presence of multiple drug efflux pumps on the chromosomes significantly contributes to their resistance to nearly all commonly used antibiotics. Given these findings, it is imperative to develop and implement effective strategies to curb the dissemination and prevalence of these highly resistant strains.
Authors
- Liman Ma
- X Ruan (ORCID: https://orcid.org/0009-0004-0624-2120)
- Dongguo Wang
- Wenji Wang (ORCID: https://orcid.org/0000-0003-1662-2130)
Institutions
- Taizhou Municipal Hospital (CN)
- Taizhou Central Hospital (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.jiph.2025.102850
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Health of Zhejiang Province
- Natural Science Foundation of Zhejiang Province