Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population
The CXADR is highlighted as a potential novel susceptibility locus for asthma exacerbations, possibly tied to viral respiratory infections. Further replication and validation are needed.
Authors
- Esther Herrera‐Luis (ORCID: https://orcid.org/0000-0003-4150-5454)
- Hatilla dos S. Silva
- Kathleen C. Barnes (ORCID: https://orcid.org/0000-0002-3030-4705)
- Simone Hashimoto (ORCID: https://orcid.org/0000-0001-8995-3817)
- Nicholas Rafaels (ORCID: https://orcid.org/0000-0002-2024-629X)
- Mahmoud I. Abdel‐Aziz (ORCID: https://orcid.org/0000-0001-9263-7137)
- Ryan dos Santos Costa (ORCID: https://orcid.org/0000-0003-3075-0729)
- Anke H. Maitland‐van der Zee (ORCID: https://orcid.org/0000-0002-0414-3442)
- Helena Mariana Pitangueira Teixeira
- Sven‐Erik Dahlén (ORCID: https://orcid.org/0000-0002-4993-4002)
- Camila Alexandrina Figueiredo (ORCID: https://orcid.org/0000-0003-1356-6188)
- Susanne J. H. Vijverberg (ORCID: https://orcid.org/0000-0002-4579-4081)
- Kian Fan Chung (ORCID: https://orcid.org/0000-0001-7101-1426)
- Tonya M. Brunetti (ORCID: https://orcid.org/0000-0002-2228-2198)
- Ratko Djukanović (ORCID: https://orcid.org/0000-0001-6039-5612)
- Maria Pino‐Yanes (ORCID: https://orcid.org/0000-0003-0332-437X)
- Álvaro Augusto Cruz (ORCID: https://orcid.org/0000-0002-7403-3871)
- Ian Michael Adcock (ORCID: https://orcid.org/0000-0003-2101-8843)
- Maria Borges Rabêlo de Santana (ORCID: https://orcid.org/0000-0001-9455-8440)
- Corey Cox (ORCID: https://orcid.org/0000-0001-9042-5982)
- Esteban G. Burchard (ORCID: https://orcid.org/0000-0001-7475-2035)
- Monica Campbell
Institutions
- Universidade Federal da Bahia (BR)
- Fundação de Amparo à Pesquisa do Estado da Bahia (BR)
- Johns Hopkins University (US)
- Universidad de La Laguna (ES)
- University of California, San Francisco (US)
- Instituto de Salud Carlos III (ES)
- Amsterdam University Medical Centers (NL)
- Imperial College London (GB)
- University of Amsterdam (NL)
- Assiut University (EG)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.jacig.2025.100507
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação de Amparo à Pesquisa do Estado da Bahia