Generation of two human induced pluripotent stem cell lines from peripheral blood mononuclear cells featuring normal or mutated STAB1 gene
Here, we report the establishment of a human induced pluripotent stem cell (hiPSC) line TUR-STAB1-B1 derived from peripheral blood mononuclear cells of a patient carrying heterozygous mutations 52,509,890 C>A 790L>I and 52,520,515 G>A 1872R>H on STAB1 gene in addition to a normal control cell line TUR-B1. The pluripotency, identity, quality, safety, and sequence of the mutation sites of the cell lines were confirmed. The generated patient-specific cell line will facilitate detailed studies of the STAB1 in various differentiated cell types.
Authors
- Elisa Närvä (ORCID: https://orcid.org/0000-0003-0517-9436)
- Nikolaos Giannareas (ORCID: https://orcid.org/0000-0002-3047-6072)
- Maija Hollmén (ORCID: https://orcid.org/0000-0002-3250-7653)
- Mikko Seppänen (ORCID: https://orcid.org/0000-0001-9733-3650)
- Sanne Sandelin (ORCID: https://orcid.org/0009-0000-1261-6812)
- Juha Kere (ORCID: https://orcid.org/0000-0003-1974-0271)
Institutions
- University of Helsinki (FI)
- University of Turku (FI)
- Helsinki University Hospital (FI)
- Turku University Hospital (FI)
- Folkhälsans Forskningscentrum (FI)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1016/j.scr.2025.103750
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Punainen Risti Veripalvelu
- Emil Aaltosen Säätiö
- Lastentautien Tutkimussäätiö
- Sigrid Juséliuksen Säätiö